A DOUBLE BLIND COMPARATIVE STUDY OF I. V. CLONIDINE AND FENTANYL TO SEE THE HAEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND ITUBATION

CORRESPONDING AUTHOR:
Dr. Nameirakpam Charan,
Department of Anaesthesiology,
JNIMS, Porompat,
Imphal-East-795005,
Manipur.
Email: bengdong29@yahoo.co.in

ABSTRACT: In the present study we have compared Clonidine (1µg/kg) and Fentanyl (2µg/kg) with minimum equipotent doses to attenuate the pressure response and at the same time avoiding the adverse effects of the respective drugs. After getting permission from the Ethical committee, a randomized double blinded study carried out in Department of Anesthesiology, JNMC, Sawangi (Meghe), Wardha, Maharashtra (India). The study comprises of 100 patients of both gender between 25 to 65 yrs. with Mallampatti grade I & II between ASA grade 1&2. They were randomly allocated into 2 groups of 50 each. Statstical analyses were done with Z test. Intravenous Clonidine was found to be more effective than intravenous Fentanyl in attenuating pressure response to laryngoscopy and intubation with the minimum equipotent dose.

KEYWORDS: Clonidine, Fentanyl, laryngoscopy, Intubation and Stress response.