STUDY OF CEFTRIAXONE VERSUS MULTIPLE DRUGS IN CAESAREAN SECTION

CORRESPONDING AUTHOR:
Dr. Raghunath Shinde,
Assistant Professor,
Department of Obstetrics and Gynaecology,
Bharati Vidyapeeth Deemed University Medical
College and Hospital, Sangli – 416416.
E-mail: sharahul13@yahoo.com

ABSTRACT: BACKGROUND: The incidence of caesarean section has increased. Maternal morbidity has also increased. Inadvertent use of antibiotics many drug resistant microbial strains have emerged. Management of post caesarean wound infection becoming difficult. Attempts have been made to bring down such infections by taking all aseptic precautions and use of minimal possible effective dose of prophylactic antibiotic or antibiotics post operatively. The purpose of this study to evaluate the effectiveness of single dose antibiotic in uncomplicated caesarean section. OBJECTIVES: To evaluate the effectiveness of single dose of ceftriaxone prophylaxis to that of ampicillin, gentamicin and metronidazole for 5 days post-operatively with regard to post-operative complications in uncomplicated caesarean sections. MATERIAL & METHODS: Hundred registered patients were selected among the pregnant women who underwent caesarean section in Obstetrics & Gynaecology department in Bharati Hospital, Sangli for a period of 1 year from December 2013 to November 2014. This study compares the drug efficacy of prophylactic single dose injection of ceftriaxone 1gm given intravenously 30 minutes prior to caesarean section with the control group of injection Ampicillin, + Gentamicin, Metronidazole given routinely for 5 days post operatively to prevent postoperative infection. In single dose antibiotic 50 patients and in control group 50 patients were studied. RESULT: Failure rate in single dose antibiotic was 2.0% (1 out of 50) and failure rate in multiple dose antibiotics was 6.0% (3 out of 50). Average duration of hospital stay was about 7 to 8 days. In all failure patients antibiotic were given according to culture and sensitivity report. CONCLUSION: Prophylactic single dose antibiotic is effective in reducing infective morbidity in low risk patients and also reduces chances of drug resistant in future.

KEYWORDS: Prophylaxis, caesarean section, ceftriaxone, Ampicillin, + Gentamicin, Metronidazole, morbidity, hospital stay, cost effectiveness.