EVALUATION OF MEAN PLATELET VOLUME AS A PROGNOSTIC MARKER IN TYPE II DIABETES MELLITUS

CORRESPONDING AUTHOR:
Dr. Navya B. N,
Assistant Professor,
Department of Pathology,
KVG Medical College and Hospital,
Sullia, D. K. District, India-574327.
E-mail: navyabn@rediffmail.com

ABSTRACT: BACKGROUND: Diabetes mellitus (DM) is both metabolic disorder and a major worldwide health problem because of its high prevalence and mortality. The prevalence of cardiovascular complication of type II DM may be associated with glycosylated hemoglobin (HbA1c) and mean platelet volume (MPV). AIM: 1. To investigate if platelets were activated in diabetes and its associated complications by measuring the MPV in diabetics compared to non-diabetics. 2. To determine the correlation of MPV among diabetics with Fasting blood Glucose levels (FBS), HbA1c, duration and complications of diabetes respectively. MATERIALS AND METHODS: A prospective study was carried on 200 diabetic patients and 200 control subjects. Both the groups underwent thorough clinical examination in terms of complications and duration of diabetes and laboratory investigations was performed. Laboratory investigations such as haemoglobin (Hb), white blood count (WBC), platelet count (Plt), MPV, FBS and HbA1c values of the participants were recorded. RESULTS: We could find significant increase in MPV among diabetics (8.83 ±0.72 fl) when compared to non-diabetics (7.62±0.47 fl) with a P value of 0.001. MPV showed a strong positive correlation with fasting blood glucose level, HbA1c levels, duration and complication of DM. CONCLUSION: MPV is associated with increase in FBS, HbA1c, duration and complications associated with DM. Therefore, MPV might be a useful prognostic marker of cardiovascular complications in patients with type II DM.

KEYWORDS: MPV, DM, HbA1c.