COMPARATIVE STUDY OF THE EFFECT OF CLOMIPHENE CITRATE AND LETROZOLE FOR INDUCTION OF OVULATION IN PRIMARY INFERTILITY.

Corresponding Author:
Dr. Pandurangaiah R,
Assistant Professor,
Department of Obstetrics and Gynaecology,
Kannur Medical College, Kannur, Kerala, India.
E-mail: pandu.medico@gmail.com

ABSTRACT

BACKGROUND

About 40% cases of infertility are due to failure of ovulation.¹ Ovulation has two major components, folliculogenesis and true ovulation.² Many a protocol has been envisaged using a type of permutation and combination mode by various hormones and drugs. A few among them are FSH, clomiphene citrate and letrozole.

Aim: In the present study, effect of clomiphene citrate is compared with letrozole for induction of ovulation.

MATERIALS AND METHODS

This is a non-randomised controlled trial study conducted during a period of over one year from 10 December 2016 to 31 March 2018, where 100 cases of primary infertility with failure of ovulation were selected. Cases were equally divided into two groups. Letrozole (n= 50) and clomiphene (n= 50) were given to each group. Folliculogenesis and ovulation were monitored by ultrasound starting from the eleventh day of the first menstrual date. The sample size estimation was also done at convenience.

RESULTS

Ovulation rate with letrozole is 64% and that with clomiphene citrate is 46%, which is statistically significant (p < 0.001).

CONCLUSION

Letrozole is superior to clomiphene citrate to affect ovulation in case of primary infertility.

KEY WORDS

Primary Infertility, Folliculogenesis, Letrozole, Clomiphene Citrate, Induction of Ovulation.