TO EVALUATE THE HAEMODYNAMIC EFFECTS OF ETOMIDATE AND A COMBINATION OF ETOMIDATE AND PROPOFOL AS INDUCTION AGENTS IN ELECTIVE SURGERIES.

Corresponding Author:
Dr. Manisha Bhatt Dwivedi,
Department of Anaesthesia,
Maharishi Markandeshwar Institute of Medical Sciences,
Mullana, Haryana, India.
E-mail: manishabhattdwivedi@gmail.com

ABSTRACT

BACKGROUND

Haemodynamic changes during laryngoscopy and intubation are the major concern during induction under general anaesthesia. Our study aims to compare the haemodynamic changes between etomidate versus a combination of etomidate and propofol.

MATERIALS AND METHODS

Sixty patients in age group of 18-50 years of ASA grade I and II were divided randomly into two groups of thirty patients each. Haemodynamic data was observed and compared. Sample size was taken for convenience.

RESULTS

Statistically significant difference was found in heart rate (p=0.000 at induction; p=0.0001 at 1 min after intubation) and MAP in both the groups at 0 min (p=0.0008) and after 1 minute (p=0.004) of induction with haemodynamic parameters significantly higher in etomidate group than the etofol group. There was no statistically significant difference at 2 mins, 5 mins, 10 mins, 20 mins, 30 mins and 60 mins between the two groups.

CONCLUSION

The combination of etomidate and propofol is an alternative to etomidate alone in patients where laryngoscopic response to haemodynamic parameters is a concern.

KEY WORDS

Haemodynamic, Induction, Propofol, Etomidate