Table of Contents

2019 Month : July Volume : 8 Issue : 30 Page : 2385-2389

ROLE OF SERUM CRP AND SERUM LDH IN PREDICTING SEVERITY OF PANCREATITIS- A PROSPECTIVE STUDY.

Archana Chilakala1, S. Fasiulla2, Vijay Krishnamurthy3

Corresponding Author:
Dr. Archana Chilakala,
Assistant Professor, Department of General Surgery,
Sri Venkateswara Medical College and
SVRRGG Hospital, Tirupati-517501, Andhra Pradesh, India.
E-mail: archana.chilakala@gmail.com

ABSTRACT

BACKGROUND

Acute pancreatitis is a common disease with a wide clinical variation and its incidence is increasing.1,2,3 About 25% of patients with acute pancreatitis develop the severe form. The average mortality rate in severe acute pancreatitis is about 2-10%.4 New serum markers have recently emerged and their potential for rapid scoring of the disease severity in the acute phase are evaluated and some of them might be used as potential therapeutic targets.

METHODS

This is a prospective analytical study. Patients more than 18 years of age, of both sexes, with elevated serum pancreatic enzymes, diagnosed of acute pancreatitis and confirmed with imaging studies were included in the study. Patients who had chronic pancreatitis, irrespective of age and sex were excluded.

RESULTS

Serum CRP and serum LDH levels tend to have an excellent accuracy in predicting the severity in acute pancreatitis.

CONCLUSIONS

Acute pancreatitis is a condition associated with high morbidity and mortality. The sensitivity and specificity of both serum CRP and LDH were excellent in predicting the severity of acute pancreatitis even on day 1 on par with traditional scoring systems. Both LDH and CRP are simple, easily available, economical biochemical parameters to predict the severity of acute pancreatitis in the early phase of disease.

KEY WORDS

Serum CRP, Serum LDH, Acute Pancreatitis, Serum Amylase, Serum Lipase

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