CHANGES IN LIVER IN CASE OF INSECTICIDAL AND ALCOHOL POISONING: AN AUTOPSY STUDY

CORRESPONDING AUTHOR:
Dr. Subhasish Saha,
Kamineni Institute of Medical Sciences,
Staff Quarter D II/3,
Narketpally, Nalgonda-508254,
Andhra Pradesh.
E-mail: drsubhasishsaha83@gmail.com

Abstract: Poison is a substance introduced in the body to produce ill-effect, disease or death. It may be of any origin like synthetic, mineral, animal or vegetable. Death due to poisoning is mostly prevalent in the developing countries, of the total burden of acute pesticide poisoning; the majority of deaths are from deliberate self-poisoning with organophosphorus pesticides, aluminium phosphide and paraquat. Exposure to pesticides is usually occupational, accidental or suicidal. In India very few research works have been undertaken on histopathological changes of liver in different poisoning. In this part of our country a sizable number of cases of poisoning due to insecticides & alcohol are reported. So this current study intends to find out different histopathological changes of liver in insecticidal & alcohol poisoning with regards to time interval between poisoning and death. In our 1 year (November 2012-October 2013) of study we got 143 victims who died due to insecticidal and alcohol poisoning, out of which 132 cases show significant histopathological changes in liver. In this study male subjects (60.83%) outnumber female (39.17%) victims and most common age group affected in this study is between 20-40 years. This study show 29.37% victims died due to organophosphorus poisoning, 25.17% cases of organochlorine poisoning, 11.88% study subjects from carbamate poisoning, 18.88% cases died due to combined alcohol and insecticidal poisoning, and 14.68% victims died due to alcohol poisoning. On microscopically 25.87% of cases show centrilobular necrosis(CN), sinusoidal dilatation(SD) found in 22.37%, fatty changes(FC) in 11.88%,both venous congestion(VC), combined sinusoidal dilatation and degenerative change in 1.39% of cases, each 2.09% of cases show degenerative change(DC), centrilobular necrosis and venous congestion, and sinusoidal dilatation and venous congestion respectively, each 3.49% show combined centrilobular necrosis and sinusoidal dilatation, fatty change and degenerative change respectively, 08.39% of cases show centrilobular necrosis and fatty change, 06.99% cases show sinusoidal dilatation and fatty change, 07.69% have no significant histopathological changes, 0.69% case show centrilobular necrosis and degenerative change.

KeyWords: Histopathology, poison, centrilobular necrosis, fatty change, sinusoidal dilatation.