COMPARISON OF C REACTIVE PROTEIN IN VARIOUS HIGH RISK GROUP DURING PREGNANCY

CORRESPONDING AUTHOR:
Dr. Rituparna Das,
B 44, Old Girls hostel,
Dr. D. Y. Patil Medical College,
Sant Tukaram Nagar,
Pimpri, Pune -411018.
E-mail: rituparnadas@yahoo.com

BACKGROUND: Common disorders of pregnancy are Hypertensive Disorders, Premature Rupture of Membrane and premature birth. Maternal health is especially affected when preeclampsia or more severe complications such as eclampsia or HELLP syndrome develops. C-reactive protein (CRP) is an abnormal serum glycoprotein produced by the liver during acute inflammation. Its production regulates by Interleukins 1b and 6 and tumour necrosis factor. Also, it had been a measure of acute phase reactions to inflammation for the last 15 years. Therefore, the aim of this study to determine diagnostic value of C-reactive protein (CRP) during pregnancy complicated by premature rupture of the membranes (PROM) .Preterm labour and its subsequent complications makes it common,costly and catastrophic complications.  OBJECTIVE: Comparison of CRP in Case and Controls.  MATERIALS AND METHODS: A comparative case control study was conducted on randomly selected 200 patients with clinically diagnosed preeclampsia prelabour rupture of membrane and preterm labour  in their third trimester attending outpatient department or admitted  in Department of Obstetrics and Gynaecology Padmashree Dr. D.Y.Patil Medical College, Hospital & Research Centre, Pimpri, Pune. RESULTS:  Out of 40 cases of Preeclampsia 34 were showed positive C reactive protein, and out of total 30 cases of both preterm labor and pre rupture of membranes both showed 18 cases positive for C reactive protein individually whereas out of 100 controls only 2 came out positive for C reactive protein

KEYWORDS: C reactive protein, Premature rupture of membranes(PROM), Preeclampsia, Preterm.