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Year : 2020 Month : August Volume : 9 Issue : 32 Page : 2296-2300

Role of Vitamins and Minerals in Improving Immunity during Covid-19 Pandemic - A Review.

Archana Dhok1, Lata Kanyal Butola2, Ashish Anjankar3, Amol Datta Rao Shinde4, Prakash Kesharao Kute5, Roshan Kumar Jha6


1Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India. 2Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India. 3Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India. 4Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India. 5Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India. 6Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India.

CORRESPONDING AUTHOR

Lata Kanyal Butola, Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India.
Email : kanyallata1010@gmail.com

ABSTRACT

Background

The COVID-19 pandemic has brought attention to the role of the immune system. The immune system can be strengthened by diet, supplements and good hygiene practices. The immune system is comprised of different cells contained in the blood, lymph, and tissues that are distributed across the body. A large number of cells and even greater numbers of chemical messengers engage in the body's immune defence. In immune response blood cells, B-lymphocytes and T- lymphocytes play a vital role. The world health organization, urges people to follow a healthier lifestyle, saying it will increase their chances of a quick recovery. Proper nutrition is required for proper functioning of immune system. Therefore, healthy balanced diet is the best way to support the immune function. Vitamins and minerals are important ingredients of the diet that the body requires to work properly. Vit D is required in limited amounts to maintain good health. Vitamins and minerals together are also called micronutrients, as they are required in very small quantities. On the other hand, carbs, proteins and fats are altogether termed as macronutrients. In recent years, vitamins A, C, D, and E, believed to have an effect on the immune system, have gained significant attention because they are involved in enhancement of immune systems. Solely, vit-A is involved in proper functioning of eye, immune system and also takes care of skin and genes. In green leafy vegetables, carrots, pumpkin, melons and mangoes vitamins are present in form of pre-vitamins, and further converted into active vit A inside the human body. It is surprising that liver, yolk of egg, butter, whole milk, and cheese are active source of vitamin A. Having a healthy diet including lots of fruits, vegetables is a key component of healthy lifestyles and plays a crucial role in maintaining a properly functioning and efficient immune system to defend against infections and other diseases. All the data was assessed from online search (PubMed, Google Scholar). In this review article we concentrate on vitamins and minerals.

 

Key words

Immunity, Vitamins, Minerals, COVID-19

BACKGROUND

The immune system has unique protective functions against infections. Bacteria that invade give raise to two radically different types of responses. Innate immunity is natural; its responses are similar to the infectious agent encountered, while acquired immunity is adaptive immunity; its responses rises strongly to repeated exposure to specific infection. Phagocytic cells, cells releasing inflammatory mediators and natural killers are types of innate responses.[1] Immunity is a diverse and redundant system that needs all of the nutrients to work properly. The immune response can be divided into three phases: reaction, control, and end reaction. The nutrient needs are greater during the response due to the need for mediator cell proliferation and synthesis.[2]

 

 

CONCLUSIONS

Immune system is highly dependent on micronutrients. Its deficiencies have high impact on the immune system. Proper amount of antioxidant neutralizer is useful in prevention of immune cells because phagocytes contain ROS as part of defence system against infection. Diet is considered as a good source for providing most of the antioxidants although a higher dose of antioxidants has been suggested to boost the body’s immune system. The immune system operates at all times but in the presence of pathogens, unique immunity becomes more and more active. Carbohydrates, proteins and fats produces energy, involving electron transport chain and various coenzymes that are derivatives of vitamins. Fe and Cu are present in ETC which are essential for proper functioning of the immune cells. Vitamin A, D, other nutrients, and their metabolites regulate gene expression of immune cells. It also plays vital role in maturation, differentiation and responsiveness of immune cells in the host. In the light of above review, role of nutrients in maintenance of immune system is clearly observed and present review findings suggest that sufficient and balanced supply of nutrients is necessary for proper functioning of the immune system.

REFERENCES

1

Delves PJ, Roitt IM. The immune system. First of two parts. N Engl J Med 2000;343(1):37-49.                            

CrossRef | Google Scholar | PubMed
2

Percival SS. Nutrition and immunity: balancing diet and immune function. Nutrition Today 2011;46(1):12-7.                  

Google Scholar |
3

Sorice A, Guerriero E, Capone F, et al. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini Rev Med Chem 2014;14(5):444-52.

CrossRef | Google Scholar | PubMed
4

Moriguchi S, Muraga E. Vitamin E and immunity. Vitam Horm 2000;59:305-36.                          

CrossRef | Google Scholar | PubMed
5

Meydani SN, Fawzi WW, Sun NH. The effect of vitamin deficiencies (E and A) and supplementation on infection and immune response. In: Tontisirin K, Suskind R, ed. Nutrition, immunity and infection disease in infants and children, 45th Nestle Nutrition Workshop. Nestle Nutrition Services 2001;45:213-41.

6

Lemire JM, Archer DC, Beck L, et al. Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr 1995;125(6 Suppl):1704S-8.         

CrossRef | Google Scholar | PubMed
7

Lemire JM, Adams JS, Sakai R, et al. 1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 1984;74(2):657-61.                        

CrossRef | Google Scholar | PubMed
8

Boonstra A, Barrat FJ, Crain C, et al. 1alpha,25-dihydroxyvitamin d3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells. J Immunol 2001;167(9):4974-80.                    

CrossRef | Google Scholar | PubMed
9

Gregori S, Giarratana N, Smiroldo S, et al. A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002;51(5):1367-74.                   

CrossRef | Google Scholar | PubMed
10

Sherman AR, Spear AT. Iron and immunity. In: Klurfeld DM, ed. Nutrition and immunology. New York and London: Plenum Press 1993:285-307.       

11

Kumar V, Choudhry VP. Iron deficiency and infection. Indian J Pediatr 2010;77(7):789-93.                   

CrossRef | Google Scholar | PubMed
12

Murray MJ, Murray AB, Murray MB, et al. The adverse effect of iron repletion on the course of certain infections. Br Med J 1978;2(6145):1113-5.    

CrossRef | Google Scholar | PubMed
13

Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr 2001;131(2S-2):616S-35S.        

CrossRef | Google Scholar | PubMed
14

Iwata M, Hirakiyama A, Eshima Y, et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004;21(4):527-38.               

CrossRef | Google Scholar | PubMed
15

Fraker PJ, King LE, Garvy BA, et al. The immunopathology of zinc deficiency in humans and rodents: a possible role for programmed cell death. In: Klurfeld DM, ed. Nutrition and Immunology. New York and London: Plenum Press 1993:267-83.

16

Fraker PJ, King LE. Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr 2004;24:277-98.            

CrossRef | Google Scholar | PubMed
17

Allen JL, Perri RT, McClain CJ, et al. Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency. J Lab Clin Med 1983;102(4):577-89.                       

Google Scholar | PubMed
18

Kryukov GV, Gladyshev VN. Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatic methods. In: Sies H, Packer L, eds. Methods in enzymology 347. San Diego, CA: Academic Press 2002:84-100.

19

Lescure A, Gautheret D, Krol A. Novel selenoproteins identified from genomic sequence data. In: Sies H, Packer L, eds. Methods in enzymology 347. San Diego, CA: Academic Press 2002:57-70.

20

Arthur JR. The glutathione peroxidases. Cell Mol Life Sci 2000;57(13-14):1825-35.                

CrossRef | Google Scholar | PubMed
21

Arthur JR. The glutathione peroxidases. Cell Mol Life Sci 2000;57(13-14):1825-35.                

CrossRef | Google Scholar | PubMed
22

Pfeifer H, Conrad M, Roethlein D, et al. Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. FASEB J 2001;15(7):1236-8.               

Google Scholar | PubMed
23

Miller S, Walker SW, Arthur JR, et al. Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase. Clin Sci (Lond) 2001;100(5):543-50.                 

Google Scholar | PubMed
24

Slavin JL, Lloyd B. Health Benefits of fruits and vegetables. Adv Nutr 2012;3(4):506-16.               

CrossRef | Google Scholar | PubMed
25

Kaur C, Kapoor HC. Antioxidants in fruits and vegetables: the millennium's health. Int J Food Sci Technol 2001;36(7):703-25.               

Google Scholar |
26

Anderson JPS, Young L, Prior S. Dietary fibre fact. Sheet No. 9.333. Colorado State University: Fort Collins, CO, USA 2010. http://www.ext.colostate.edu/pubs/foodnut/ 09333.pdf

27

Lattimer JM, Haub MD. Effects of dietary fibre and its components on metabolic health. Nutrients 2010;2(12):1266-89.      

CrossRef | Google Scholar | PubMed
28

Lattimer JM, Haub MD. Effects of dietary fibre and its components on metabolic health. Nutrients 2010;2(12):1266-89.      

CrossRef | Google Scholar | PubMed
29

Adebawo O, Salau B, Ezima E, et al. Fruits and vegetables moderate lipid cardiovascular risk factor in hypertensive patients. Lipids Health Dis 2006;5:14.  

CrossRef | Google Scholar | PubMed
30

Kumar M, Axelrod AE. Cellular antibody synthesis in vitamin B6-deficient rats. The Journal of Nutrition 1968;96(1):53-9.             

Google Scholar |
31

Doke S, Inagaki N, Hayakawa T, et al. Effect of vitamin B6 deficiency on an antibody production in mice. Biosci Biotechnol Biochem 1997;61(8):1331-6.

CrossRef | Google Scholar | PubMed
32

Inubushi T, Okada M, Matsui A, et al. Effect of dietary vitamin B6 contents on antibody production. BioFactors 2000;11(1-2):93-6.             

Google Scholar |
33

Lotto V, Choi SW, Friso S. Vitamin B6: a challenging link between nutrition and inflammation in CVD. Br J Nutr 2011;106(2):183-95.                  

CrossRef | Google Scholar | PubMed
34

Rimando AM, Suh N. Natural products and dietary prevention of cancer. Mol Nutr Food Res 2008;52 Suppl 1:S5.           

CrossRef | Google Scholar | PubMed
35

Wu XY, Lu L. Vitamin B6 deficiency, genome instability and cancer. Asian Pac J Cancer Prev 2012;13(11)5333-8.            

CrossRef | PubMed
36

Galluzzi L, Vacchelli E, Michels J, et al. Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses. Oncogene 2013;32(42):4995-5004.                 

Google Scholar |
37

Tamura J, Kubota K, Murakami H, et al. Immunomodulation by vitamin B 12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B 12 -deficient patients by methyl-B 12 treatment. Clin Exp Immunol 1999;116:28-34. 

Google Scholar |

DISCLOSURE AND FUNDING

Disclosure forms provided by the authors are available with the full text of this article at jemds.com

ICMJE Forms

Financial or Other Competing Interests: None.

How to cite this article

Dhok A, Butola LK, Anjankar A, et al. Role of vitamins and minerals to improve immunity during covid-19 pandemic- a review. J. Evolution Med. Dent. Sci. 2020;9(32):2296-2300, DOI: 10.14260/jemds/2020/497

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