Spectrum of Lesions on Upper Gastrointestinal Endoscopy and Its Correlation with Histopathological Evaluation.
Preeti Rajendra Sahu1, Kishor Madhukar Hiwale2, Sunita Jayant Vagha3, Samarth Shukla4
1Department of Pathology, Jawaharlal Nehru Medical College, Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, Maharashtra, India. 2Department of Pathology, Jawaharlal Nehru Medical College, Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, Maharashtra, India. 3Department of Pathology, Jawaharlal Nehru Medical College, Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, Maharashtra, India. 4Department of Pathology, Jawaharlal Nehru Medical College, Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), Wardha, Maharashtra, India.
CORRESPONDING AUTHOR
Department of Pathology, Jawaharlal Nehru Medical College, Acharya Vinoba Bhave Rural Hospital, Sawangi, Meghe, Wardha, Maharashtra, India.
Email : preetisahu9811@gmail.com
ABSTRACT
Gastrointestinal (GI) diseases present with symptoms of abdominal pain, heartburn, diarrhoea, nausea, vomiting, flatulence, difficulty in swallowing, dysphagia, bloated abdomen, significant weight loss, fullness after having very little meal, and melena. Taking into account of just the upper GI bleed incidence, it ranges from 50 to 150/100,000 population annually, and time trend analyses suggest that aged people constitute an increasing proportion of those presenting with acute upper GI bleed.1
An upper GI endoscopy or oesophagogastroduodenoscopy/ EGD aids in diagnosing and treating disorders of upper GIT. Endoscopy gives a visual look of GI mucosa and allows tissue sampling, for further assessment by pathologist. Abnormal endoscopic appearance indicates a disease, where biopsy will confirm.2 Histopathological examination (HPE) is the best confirmatory tool to confirm and find the diagnosis.3
Various lesions affecting THE GIT are classified organ wise i.e. oesophageal, gastric and duodenal lesions. Clinical history remains central in evaluating oesophageal symptoms. Chief oesophageal symptoms are pyrosis, reflux, chest pain, dysphagia and odynophagia. Heartburn/pyrosis, is most frequent intermittent oesophageal symptom, presenting as an uneasiness/ burning sensation in retrosternum radiating toward neck. It occurs mostly after eating/while lying recumbent.4
BACKGROUND
Gastrointestinal (GI) diseases present with symptoms of abdominal pain, heartburn, diarrhoea, nausea, vomiting, flatulence, difficulty in swallowing, dysphagia, bloated abdomen, significant weight loss, fullness after having very little meal, and melena. Taking into account of just the upper GI bleed incidence, it ranges from 50 to 150/100,000 population annually, and time trend analyses suggest that aged people constitute an increasing proportion of those presenting with acute upper GI bleed.1
An upper GI endoscopy or oesophagogastroduodenoscopy/ EGD aids in diagnosing and treating disorders of upper GIT. Endoscopy gives a visual look of GI mucosa and allows tissue sampling, for further assessment by pathologist. Abnormal endoscopic appearance indicates a disease, where biopsy will confirm.2 Histopathological examination (HPE) is the best confirmatory tool to confirm and find the diagnosis.3
Various lesions affecting THE GIT are classified organ wise i.e. oesophageal, gastric and duodenal lesions. Clinical history remains central in evaluating oesophageal symptoms. Chief oesophageal symptoms are pyrosis, reflux, chest pain, dysphagia and odynophagia. Heartburn/pyrosis, is most frequent intermittent oesophageal symptom, presenting as an uneasiness/ burning sensation in retrosternum radiating toward neck. It occurs mostly after eating/while lying recumbent.4
REFERENCES
Thomopoulos KC, Vagenas KA, Vagianos CE, et al. Changes in aetiology and clinical outcome of acute upper gastrointestinal bleeding during the last 15 years. Eur J Gastroenterol Hepatol 2004;16(2):177-82.
CrossRef | Google Scholar | PubMedTeriaky A, AlNasser A, McLean C, et al. The utility of endoscopic biopsies in patients with normal upper endoscopy. Can J Gastroenterol Hepatol 2016;2016:1-7.
CrossRef | Google Scholar | PubMedSwarnkar M, Jain SC. Heterotopic subserosal pancreatic tissue in jejunum-an incidental rare finding. JKIMSU 2017;6(4):105-8.
CrossRef | Google Scholar |Kahrilas PJ, Hirano I. Diseases of the esophagus. In: Kasper D, Fauci A, Hauser S, et al, eds. Harrison’s principles of internal medicine. 19th edn. McGraw-Hill Medical 2015.
Peixoto A, Silva M, Pereira P, et al. Biopsies in gastrointestinal endoscopy: when and how. GE Port J Gastroenterol 2015;23(1):19-27.
CrossRef | Google Scholar | PubMedConner JR, Kirsch R. The pathology and causes of tissue eosinophilia in the gastrointestinal tract. Histopathology 2017;71(2):177-99.
CrossRef | Google Scholar | PubMedAmornyotin S. Endoscopy of GI tract. Intech Open 2013: p. 362.
Amornyotin S. Endoscopy of GI tract. Intech Open 2013: p. 362.
Amornyotin S. Endoscopy of GI tract. Intech Open 2013: p. 362.
Kulkarni M, Agrawal T, Dhas V. Histopathologic bodies: an insight. J Int Clin Dent Res Organ 2011;3(1):43-7.
Google Scholar |Reddy N, Wilcox CM. Diagnosis and management of cytomegalovirus infections in the GI tract. Expert Rev Gastroenterol Hepatol 2007;1(2):287-94.
CrossRef | Google Scholar | PubMedBhatia SJ, Reddy DN, Ghoshal UC, et al. Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol 2011;30(3):118-27.
CrossRef | Google Scholar | PubMedLoughrey MB, Johnston BT. Guidance on the effective use of upper gastrointestinal histopathology. Frontline Gastroenterol 2014;5(2):88-95.
CrossRef | Google Scholar | PubMedWani IR, Showkat HI, Bhargav DK, et al. Prevalence and risk factors for barrett’s esophagus in patients with GERD in Northern India; do methylene blue directed biopsies improve detection of Barrett’s esophagus. Compared the conventional method? Middle East J Dig Dis 2014;6(4):228-36.
CrossRef | Google Scholar | PubMedArnold M, Soerjomataram I, Ferlay J, et al. Global incidence of oesophageal cancer by histological subtype in 2012. Gut 2015;64(3):381-7.
CrossRef | Google Scholar | PubMedAbbas G, Krasna M. Overview of esophageal cancer. Ann Cardiothorac Surg 2017;6(2):131-6.
CrossRef | Google Scholar | PubMedLi YZ, Wu PH. Conventional radiological strategy of common gastrointestinal neoplasms. World J Radiol 2015;7(1):7-16.
CrossRef | Google Scholar | PubMedNapier KJ, Scheerer M, Misra S. Esophageal cancer: a review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol 2014;6(5):112-20.
CrossRef | Google Scholar | PubMedRosai J. Rosai and Ackerman’s surgical pathology. 9th edn. Edinburgh: Mosby 2004.
Kankaria AG, Fleischer DE. The critical care management of nonvariceal upper gastrointestinal bleeding. Crit Care Clin 1995;11(2):347-68.
Google Scholar | PubMedTerdiman JP. Update on upper gastrointestinal bleeding. Basing treatment decisions on patients’ risk level. Postgrad Med 1998;103(6):43-64
CrossRef | Google Scholar | PubMedvan Leerdam ME, Vreeburg EM, Rauws EAJ, et al. Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am J Gastroenterol 2003;98(7):1494-9.
CrossRef | Google Scholar | PubMedWroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 2010;23(4):713-39.
CrossRef | Google Scholar | PubMedRastogi T, Devesa S, Mangtani P, et al. Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and US. Int J Epidemiol 2008;37(1):147-60.
CrossRef | Google Scholar | PubMedSitarz R, Skierucha M, Mielko J, et al. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res 2018;10:239-48.
CrossRef | Google Scholar | PubMedSagaert X, De Wolf-Peeters C, Noels H, et al. The pathogenesis of MALT lymphomas: where do we stand? Leukemia 2007;21(3):389-96.
CrossRef | Google Scholar | PubMedRanjan P, Ghoshal UC, Aggarwal R, et al. Etiological spectrum of sporadic malabsorption syndrome in northern Indian adults at a tertiary hospital. Indian J Gastroenterol 2004;23(3):94-8.
Google Scholar | PubMedBao F, Green PHR, Bhagat G, et al. An update on celiac disease histopathology and the road ahead. Arch Pathol Lab Med 2012;136(7):735-45.
CrossRef | Google Scholar | PubMedHa F, Khalil H. Crohn’s disease: a clinical update. Ther Adv Gastroenterol 2015;8(6):352-9.
CrossRef | Google Scholar | PubMedRendi M, Younes M. Crohn disease pathology. https://emedicine.medscape.com/article/1986158-overview#a7
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How to cite this article
Sahu PR, Hiwale KM, Vagha SJ, et al. Spectrum of lesions on upper gastrointestinal endoscopy and its correlation with histopathological evaluation. J. Evolution Med. Dent. Sci. 2020;9(32):2301-2306, DOI: 10.14260/jemds/2020/498